CCR2(+)CCR5(+) T cells produce matrix metalloproteinase-9 and osteopontin in the pathogenesis of multiple sclerosis.

[Chemokine receptor expression of T cells in the cerebrospinal fluid of relapsing multiple sclerosis].

Multiple Sclerosis (MS) is an autoimmune-mediated chronic demyelinating disease of the central nervous system. The role of CD4+ T helper T cells in the pathogenesis of this disease is established. CD4+ T cells comprise various Th subsets, including Th1 and Th17 cells. The contributution of each T cell subset to MS pathology is not fully elucidated. As each Th subset have characteristic chemokin...

CCR2CCR5 T Cells Producing Matrix Metalloproteinase-9 and Osteopontin in the Pathogenesis of Multiple Sclerosis

Association of CCR2 Gene but not CCR5 Gene Polymorphisms with Alzheimer’s Disease

Chemokines participate in the regulation of immune and inflammatory responses by interacting with their specific receptors on related immune and inflammatory cells such as B-lymphocytes, T-lymphocytes and antigen-presenting cells. Chemokines and their receptors are therefore considered to mediate inflammation and tissue damage in autoimmune disorders. The recent studies have revealed the genoty...

Ccr2-64i and Ccr5 Δ32 Polymorphisms in Patients with Late-Onset Alzheimer’s disease; A Study from Iran (Ccr2-64i And Ccr5 Δ32 Polymorphisms in Alzheimer’s disease)

Objective(s) Alzheimer’s disease (AD) is a complex disease with multifactorial etiology. Inflammation has been proven to have an important role in the pathogenesis of AD. Both CCR2 and CCR5 genes expression increase in AD patients comparing to control subjects. CCR5 gene encodes a protein which is a member of the beta chemokine receptors family of integral membrane proteins. CCR5-Δ32 is a gene...

P170: The Role of Th1 Lymphocytes in The Pathogenesis of Multiple Sclerosis (MS)

Th1 lymphocytes produce cytokines such as IL-2, IFN-γ, and TNF-α, TNF-β and GM-CSF. IFN-γ is the most important Th1 cell cytokine that induces the production of IgG, activation of macrophages, enhancing phagocytosis, and also increasing MHC class I and class II molecules. Increasing serum level of Th1 cytokines have also been observed in MS patients. It has also been prov...